Description
Questran (active ingredient: Cholestyramine) is a bile acid sequestrant, typically used to lower cholesterol levels and to treat conditions related to bile acid buildup. Each sachet contains 4 grams of Cholestyramine powder, which is to be mixed with water or other liquids before ingestion.
Questran works by binding to bile acids in the intestine. Bile acids are made from cholesterol, and their main role is to help digest fats. By binding to bile acids, Questran prevents them from being reabsorbed into the bloodstream. This forces the liver to use up more cholesterol to produce additional bile acids, which in turn lowers the cholesterol levels in the blood, particularly low-density lipoprotein (LDL) cholesterol.
Additionally, by reducing bile acids in the gut, Questran can help relieve itching caused by liver diseases and bile acid buildup.
Indications
Questran is indicated for:
- Hypercholesterolemia: To lower elevated levels of LDL cholesterol in the blood, often in combination with diet, exercise, and other cholesterol-lowering medications.
- Bile Acid Diarrhea: To treat diarrhea caused by excess bile acids, particularly after gallbladder removal.
- Pruritus: To treat itching associated with partial biliary obstruction or liver disease where bile acid buildup occurs.
- Irritable Bowel Syndrome (IBS): Sometimes used off-label to manage symptoms of IBS related to bile acid malabsorption.
Side Effects
Common side effects of Questran include:
- Gastrointestinal Issues:
- Constipation (most common)
- Bloating
- Nausea
- Abdominal discomfort
- Indigestion
- Vitamin Deficiencies: Cholestyramine can interfere with the absorption of fat-soluble vitamins (A, D, E, K), potentially leading to deficiencies over time.
- Increased Triglycerides: Questran may increase blood triglyceride levels in some patients.
- Other:
- Flatulence
- Heartburn
Availability
Questran 50 Sachets (4g) are available in online pharmacies in Pakistan, including Eazymedz.com. As it is an imported medication, availability and pricing may vary. You may need a valid prescription from a healthcare provider to purchase it.
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